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科学家找到对抗乳腺癌的办法‘亚博APp买球首选’

作者:亚博APp买球   发布时间:2021-07-03   点击量:

本文摘要:Researchers have been able to coax human breast cancer cells to turn into fat cells in a new proof-of-concept study in mice.在对耗子进行的定义论述科学研究中,研究者能够收购人们甲状腺癌细胞更改为脂肪细胞。

Researchers have been able to coax human breast cancer cells to turn into fat cells in a new proof-of-concept study in mice.在对耗子进行的定义论述科学研究中,研究者能够收购人们甲状腺癌细胞更改为脂肪细胞。To achieve this feat, the team exploited a weird pathway that metastasising cancer cells have; their results are just a first step, but its a truly promising approach.为了更好地得到 此项贡献,精英团队运用转移癌癌细胞的独特通道。她们的結果仅仅第一步,可是显而易见是个很有发展前途的方式。

When you cut your finger, or when a foetus grows organs, the epithelium cells begin to look less like themselves, and more fluid – changing into a type of stem cell called a mesenchyme and then reforming into whatever cells the body needs.你切到手指头的情况下,胎宝宝宽人体器官的情况下,鳞状上皮细胞刚开始看起来不那麼像他们自己了,更加像“液體”,变成一种叫作质间的干细胞美容,随后变成人体务必的一切一种体细胞。This process is called epithelial-mesenchymal transition (EMT) and its been known for a while that cancer can use both this one and the opposite pathway called MET (mesenchymal‐ o‐epithelial transition), to spread throughout the body and metastasise.这一全过程叫作鳞状上皮细胞-间充质转换成(EMT)。大伙儿早就告知了一段时间,癌细胞既可以用这类方法还可以用忽视的叫作EMT(间充质-鳞状上皮细胞转换成)的方法在身体扩散移往。The researchers took mice implanted with an aggressive form of human breast cancer, and treated them with both a diabetic drug called rosiglitazone and a cancer treatment called trametinib.研究者在小鼠身体嵌入一种攻击能力的人甲状腺癌细胞,用放化疗糖尿病患者的药品罗格列酮和放化疗癌病的药品曲美家具替尼放化疗小鼠。

Thanks to these drugs, when cancer cells used one of the above-mentioned transition pathways, instead of spreading they changed from cancer into fat cells – a process called adipogenesis.好在了这种药品,当癌细胞用所述的在其中一种改变方式,而不是扩散时,他们从癌细胞更改为了更好地脂肪细胞。这类全过程叫作脂肪组成。

The models used in this study have allowed the evaluation of disseminating cancer cell adipogenesis in the immediate tumour surroundings, the team wrote in their paper, published in January 2019.精英团队在今年一月公布发布的毕业论文中提到, “此项科学研究中用以的方式允许对必需恶性肿瘤自然环境中扩散癌细胞的脂肪组成进行评定。”The results indicate that in a patient-relevant setting combined therapy with rosiglitazone and trametinib specifically targets cancer cells with increased plasticity and induces their adipogenesis.“数据显示,在与患者涉及到的自然环境中,用以罗格列酮和曲美家具替尼的治疗法特别是在对于具有延展性的癌细胞,推动他们进行脂肪组成。”Although not every cancer cell changed into a fat cell, the ones that underwent adipogenesis didnt change back.尽管并不是每一个癌细胞都是会更改为脂肪细胞,但早就再次出现了脂肪组成的体细胞会变回来。


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